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MSKCC Study uncovers Genetic Reasons Why Some People Respond to Immunotherapy Better than Others

"A new analysis finds that certain genes people are born with may play a critical role in whether or not checkpoint inhibitors will work. For some people with cancer, immunotherapy drugs called checkpoint inhibitors, which take the brakes off the immune system and allow it to attack cancer cells, have been a game changer. They can shrink even very advanced cancersto levels that can no longer be detected. But for most patients, these drugs have been disappointing. Researchers are trying to figure out why. Now the largest-ever genetic analysis of people being treated with checkpoint inhibitors has found that certain genes people are born with (called germline genes) may play a critical role." (

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